Retrospective cohort study of epitope-based virtual crossmatch allocation in a public transplant system (Pernambuco, Brazil)
Rafael Melo Santos de Serpa Brandão, Adalberto Socorro da Silva, Luís Gustavo Modelli de Andrade, Luiz Claudio Demes da Mata Sousa, João Marcelo Medeiros de Andrade, Frederico Castelo Branco Cavalcanti, Glauco Henrique Willcox, Samuel de Alencar Cavalcante, Ruy de Lima Cavalcanti Neto, Amaro Medeiros de Andrade, Alexandre de Holanda Cavalcanti Pinto, Diogo Buarque Cordeiro Cabral, Tatiana Cristina Manzi Sena dos Santos, Isa Maria Teixeira Leão, Elizabeth Lima Guimarães, Bruno de Melo Correa, André Bezerra Pereira do Rego, Semiramis Jamil Hadad do Monte · 2026
Read Retrospective cohort study of epitope-based virtual crossmatch allocation in a public transplant system (Pernambuco, Brazil) by Rafael Melo Santos de Serpa Brandão, Adalberto Socorro da Silva, Luís Gustavo Modelli de Andrade, Luiz Claudio Demes da Mata Sousa, João Marcelo Medeiros de Andrade, Frederico Castelo Branco Cavalcanti, Glauco Henrique Willcox, Samuel de Alencar Cavalcante, Ruy de Lima Cavalcanti Neto, Amaro Medeiros de Andrade, Alexandre de Holanda Cavalcanti Pinto, Diogo Buarque Cordeiro Cabral, Tatiana Cristina Manzi Sena dos Santos, Isa Maria Teixeira Leão, Elizabeth Lima Guimarães, Bruno de Melo Correa, André Bezerra Pereira do Rego, Semiramis Jamil Hadad do Monte (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13491654.txt.
Description
Rafael Melo Santos de Serpa Brandão leads a large team reporting a 2026 comparison of kidney transplant allocation eras in Pernambuco, Brazil. Candidates whose immune systems react against many donor types wait longest for a kidney. The state adopted EpViX, a system that uses detailed antibody targets, called epitopes, to run virtual crossmatches before an organ is offered.
The earlier era covered 3,136 candidates from 2005 to 2014, and the EpViX era covered 4,544 from 2016 to 2025. Transplant rates rose from about thirty-six percent to fifty percent, while median waiting time fell from twenty-two months to seven. Highly sensitized candidates gained the most ground in their first-year transplant chances. The virtual test also matched the laboratory crossmatch closely, supporting wider use.
Catalog record
| CREATOR | Rafael Melo Santos de Serpa Brandão, Adalberto Socorro da Silva, Luís Gustavo Modelli de Andrade, Luiz Claudio Demes da Mata Sousa, João Marcelo Medeiros de Andrade, Frederico Castelo Branco Cavalcanti, Glauco Henrique Willcox, Samuel de Alencar Cavalcante, Ruy de Lima Cavalcanti Neto, Amaro Medeiros de Andrade, Alexandre de Holanda Cavalcanti Pinto, Diogo Buarque Cordeiro Cabral, Tatiana Cristina Manzi Sena dos Santos, Isa Maria Teixeira Leão, Elizabeth Lima Guimarães, Bruno de Melo Correa, André Bezerra Pereira do Rego, Semiramis Jamil Hadad do Monte |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |