Development of a novel hydroxylated recombinant human type III collagen TD-1-HrHC in Komagataella phaffii with transdermal and skin damage repair activity
Yangyang Li, Yehai Wang, Jingjing Yue, Yan Fan, Shimei Qi, Haixia Yu, Funa Zhang, Jing Wu, Weihua Xiao · 2026
Read Development of a novel hydroxylated recombinant human type III collagen TD-1-HrHC in Komagataella phaffii with transdermal and skin damage repair activity by Yangyang Li, Yehai Wang, Jingjing Yue, Yan Fan, Shimei Qi, Haixia Yu, Funa Zhang, Jing Wu, Weihua Xiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13491638.txt.
Description
Yangyang Li and eight co-authors describe in 2026 an engineered collagen designed to pass through skin and help repair damage. Ordinary collagen molecules are too large to cross the skin barrier, which limits creams and medical uses. The team fused a short human type III collagen fragment to TD-1, a small peptide known to ferry proteins through skin.
The protein was produced in the yeast Komagataella phaffii together with an enzyme that adds the hydroxyl groups natural collagen carries. Lab tests showed far better skin penetration than animal collagen, and treated skin cells raised barrier and renewal factors while resisting protein damage. In mice, the protein sped repair of damaged skin and encouraged new collagen growth, supporting cosmetic and medical development.
Catalog record
| CREATOR | Yangyang Li, Yehai Wang, Jingjing Yue, Yan Fan, Shimei Qi, Haixia Yu, Funa Zhang, Jing Wu, Weihua Xiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52348 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |