Editing regulatory network in non-small cell lung cancer: implications for immunity and metastasis
Jiajin Zhang, Liyu Huang, Sijia Wu · 2026
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Description
Jiajin Zhang, Liyu Huang, and Sijia Wu propose in 2026 a network approach to RNA editing in non-small cell lung cancer. RNA editing changes letters in RNA copies of genes, and single changes have mostly been studied one at a time. The authors argue that groups of edits acting together may matter more, so they built modules of coordinated editing events.
Applied to this lung cancer, the framework found more than a dozen modules tied to immune control and to spread of the disease. Editing appeared to alter how small regulatory RNAs handle two genes, EIF2AK2 and PRKAR2A, and to affect a transcription factor called AHR plus a binding protein named DDX3X. The work offers a map for studying editing as a system rather than as isolated events.
Catalog record
| CREATOR | Jiajin Zhang, Liyu Huang, Sijia Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36698 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |