In vivo reduction of Treg expansion in rodent helminth–malaria coinfection
Luc Bourbon, Aloïs Dusuel, Nicolas Pernet, Mickaël Rialland, Benjamin Roche, Bruno Faivre, Gabriele Sorci · 2026
Read In vivo reduction of Treg expansion in rodent helminth–malaria coinfection by Luc Bourbon, Aloïs Dusuel, Nicolas Pernet, Mickaël Rialland, Benjamin Roche, Bruno Faivre, Gabriele Sorci (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13491614.txt.
Description
Luc Bourbon and six colleagues describe a 2026 mouse study of what happens when a parasitic worm and a malaria parasite infect the same host. Worms usually calm the immune system by expanding regulatory T cells, which dampen inflammation. Whether that calming holds during coinfection with a fast-growing microbe was unknown, so the team paired the nematode Heligmosomoides polygyrus with Plasmodium yoelii.
Coinfected mice showed less regulatory T cell expansion in the body than singly infected mice. Worm secretions collected from both groups still triggered equal expansion in cell culture, and worms from coinfected hosts even raised output of a calming signal gene. Breeding worms for eight generations in each setting produced no steady change. The authors conclude the host, not the worm, drives the weaker response.
Catalog record
| CREATOR | Luc Bourbon, Aloïs Dusuel, Nicolas Pernet, Mickaël Rialland, Benjamin Roche, Bruno Faivre, Gabriele Sorci |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85641 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |