Genomic characterization of drug-resistant Mycobacterium tuberculosis complex in western Kenya reveals predominance of isoniazid resistance and discordance with routine susceptibility testing
Susan Musau, Susan Odera, Victor Moses Musyoki, Eleanor I. Lamont, Noel Onyango, Bob Morrison, Wilfred Murithi, Steve Wandiga, Videlis Nduba, David Sherman, Marianne W. Mureithi · 2026
Read Genomic characterization of drug-resistant Mycobacterium tuberculosis complex in western Kenya reveals predominance of isoniazid resistance and discordance with routine susceptibility testing by Susan Musau, Susan Odera, Victor Moses Musyoki, Eleanor I. Lamont, Noel Onyango, Bob Morrison, Wilfred Murithi, Steve Wandiga, Videlis Nduba, David Sherman, Marianne W. Mureithi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13491443.txt.
Description
Susan Musau leads an author group reporting a 2026 study of drug-resistant tuberculosis bacteria from western Kenya. Routine testing in the region relies on narrow gene probes and culture methods that can miss resistance. The authors set those results against whole-genome sequencing of stored samples drawn from twelve counties.
Among 1,053 samples, about one in eight stood up to at least one drug. The largest group no longer answered to isoniazid, though rifampicin still worked on it. Sequencing of 290 good-quality genomes tied rifampicin failure mainly to the rpoB change S450L and isoniazid failure to katG and inhA promoter changes. Resistant samples grouped in four counties and in lineages 4 and 3. Routine tests and sequencing differed often enough that the authors urge using both methods.
Catalog record
| CREATOR | Susan Musau, Susan Odera, Victor Moses Musyoki, Eleanor I. Lamont, Noel Onyango, Bob Morrison, Wilfred Murithi, Steve Wandiga, Videlis Nduba, David Sherman, Marianne W. Mureithi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39356 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |