Kynurenine pathway dysregulation in attention-deficit hyperactivity disorder: Impact on N-methyl-D-aspartate receptors and phasic dopamine maturation
Takahiko Nagamine · 2026
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Description
Takahiko Nagamine, writing alone in 2026, reviewed recent findings on a chemical pathway in children with attention-deficit hyperactivity disorder. The pathway, called kynurenine, has shifted toward a more toxic profile in children who had not taken medication. Two products of the pathway stand out: one that calms a key brain receptor fell, while a more harmful one rose.
Nagamine argues that this shift may drive part of the disorder, not just mark it. Low levels of the calming product may free a receptor that shapes bursts of dopamine, which matter for focus and control. The paper also weighs a drug target on the pathway and the role of the blood-brain barrier.
Catalog record
| CREATOR | Takahiko Nagamine |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |