Associations of genetic variants in TCF7L2, MC4R, AGT and ACE genes with cardiometabolic diseases in Black South Africans
Ndonwi Elvis Ngwa, Keren de Buys, Don Makwakiwe Matshazi, Naomi S Levitt, Carl Lombard, Glenda Mary Davison, Tandi Edith Matsha, Andre Pascal Kengne, Sian Megan Joanna Hemmings, Nasheeta Peer · 2026
Read Associations of genetic variants in TCF7L2, MC4R, AGT and ACE genes with cardiometabolic diseases in Black South Africans by Ndonwi Elvis Ngwa, Keren de Buys, Don Makwakiwe Matshazi, Naomi S Levitt, Carl Lombard, Glenda Mary Davison, Tandi Edith Matsha, Andre Pascal Kengne, Sian Megan Joanna Hemmings, Nasheeta Peer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13488011.txt.
Description
Ndonwi Elvis Ngwa and co-authors test gene variants linked to diabetes, obesity, and high blood pressure in Black South Africans in a 2026 cross-sectional study. The sample held 560 adults aged twenty-five to seventy-four, who gave lifestyle details, had body measures and blood pressure taken, and completed glucose tolerance testing. Variants in genes tied to appetite, blood pressure control, and insulin signaling were typed in the laboratory.
One variant in a diabetes gene was linked with lower odds of type 2 diabetes, even after adjustment for age, sex, and body size. A variant near an appetite gene tracked with higher blood pressure and hypertension risk, though the signal weakened after adjustment. The authors call for replication in larger local samples.
Catalog record
| CREATOR | Ndonwi Elvis Ngwa, Keren de Buys, Don Makwakiwe Matshazi, Naomi S Levitt, Carl Lombard, Glenda Mary Davison, Tandi Edith Matsha, Andre Pascal Kengne, Sian Megan Joanna Hemmings, Nasheeta Peer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45101 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |