PACSIN2-mediated synaptic injury contributes to behavioral disorders caused by chronic stress
Chang-min Wang, Ye Li, Yu-hang Yi, Xiao Chen, Tian Lan, Hai-yan Lou, Wen-cheng Jian, Mei-jian Wang, Shu-yan Yu · 2026
Read PACSIN2-mediated synaptic injury contributes to behavioral disorders caused by chronic stress by Chang-min Wang, Ye Li, Yu-hang Yi, Xiao Chen, Tian Lan, Hai-yan Lou, Wen-cheng Jian, Mei-jian Wang, Shu-yan Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13487163.txt.
Description
Chang-min Wang and co-authors trace in 2026 how long-term stress damages brain connections in depression. Major depression is tied to lost synapses, the tiny junctions where brain cells talk, in areas like the hippocampus. The molecular chain from stress to that loss was not clear.
In rats, chronic stress raised levels of a protein called PACSIN2 in a key memory area. Extra copies of it made rats more prone to stress, by thinning a receptor that catches key signals. When the team dialed the protein down in stressed rats, signaling improved and depression-like behavior eased. The authors name PACSIN2 as a control point through which stress harms the brain.
Catalog record
| CREATOR | Chang-min Wang, Ye Li, Yu-hang Yi, Xiao Chen, Tian Lan, Hai-yan Lou, Wen-cheng Jian, Mei-jian Wang, Shu-yan Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |