IMP1 is a novel posttranscriptional regulator of early erythroid development and embryonic globin output∗
Katherine A. MacInnes, Ivan Ferrer-Vicens, Minna Hancock, Kongtana Trakarnsanga, Deborah E. Daniels, Marieangela C. Wilson, Jan Frayne · 2026
Read IMP1 is a novel posttranscriptional regulator of early erythroid development and embryonic globin output∗ by Katherine A. MacInnes, Ivan Ferrer-Vicens, Minna Hancock, Kongtana Trakarnsanga, Deborah E. Daniels, Marieangela C. Wilson, Jan Frayne (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13486811.txt.
Description
MacInnes and co-authors identify a new controller of early red blood cell development. Their 2026 paper studies IMP1, a protein that reads chemical marks on RNA messages and shapes which proteins get made. Embryonic red cells produce distinctive globin types, the oxygen-carrying chains, before switching to fetal and then adult forms, and the controls behind that first stage were poorly understood.
Using gene removal in early erythroid cells, protein profiling, and RNA capture methods, the team showed IMP1 helps set the fetal character of these cells. Embryonic globin output was governed directly by IMP1 after the RNA stage, rather than through gene switching alone. The authors present IMP1 as a previously unrecognised posttranscriptional regulator, meaning it acts on RNA messages after they are produced, in the earliest blood-forming stage.
Catalog record
| CREATOR | Katherine A. MacInnes, Ivan Ferrer-Vicens, Minna Hancock, Kongtana Trakarnsanga, Deborah E. Daniels, Marieangela C. Wilson, Jan Frayne |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |