An epithelial mesenchymal transition associated gene signature stratifies risk of ulcerative colitis associated colorectal cancer
Nevin Belder · 2026
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Description
Nevin Belder builds a gene signature that flags which ulcerative colitis patients are sliding toward colon cancer. Published in 2026, the single-author analysis mines transcript data from colitis and cancer cohorts separately, hunting changes that repeat across both. A cell-state program called epithelial-mesenchymal transition keeps surfacing among switched-up genes.
Twenty-four shared candidate genes narrowed to fourteen that run high in colitis-linked precancer compared with quiet colitis, each separating the states strongly. Machine learning distilled a seven-gene panel whose combined score climbs stepwise from quiet disease through precancer to cancer. Long-standing colitis carries real cancer risk, yet colonoscopy alone cannot see molecular momentum. A tissue score that rises along the danger path could focus surveillance on the patients who need it most.
Catalog record
| CREATOR | Nevin Belder |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80337 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |