Mechanistic evaluation of niosomal Rhoifolin in antileishmanial therapy and its additive potential with meglumine antimoniate
Raheleh Eftekhari Kenzerki, Mehdi Karamian, Iraj Sharifi, Abbas Pardakhty, Hamidreza Kheiri, Ehsan Salarkia, Alireza Keyhani · 2026
Read Mechanistic evaluation of niosomal Rhoifolin in antileishmanial therapy and its additive potential with meglumine antimoniate by Raheleh Eftekhari Kenzerki, Mehdi Karamian, Iraj Sharifi, Abbas Pardakhty, Hamidreza Kheiri, Ehsan Salarkia, Alireza Keyhani (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13483862.txt.
Description
Eftekhari Kenzerki and team packaged a plant compound into tiny fat bubbles to fight the parasite behind leishmaniasis, a neglected tropical disease spread by sandflies. The compound, rhoifolin, was sealed inside niosomes, simple soap-like carriers that release cargo slowly. Their 2026 study tested free and packaged rhoifolin, alone and with the standard drug meglumine antimoniate, against Leishmania major in dishes and inside infected immune cells.
The packaging trapped about 91 percent of the compound and released it steadily over time. Packaged rhoifolin killed both free-swimming parasites and the form hiding inside macrophages better than the free compound did. Mixing either version with the standard drug gave additive effects and better safety margins for host cells. Treated parasites switched on self-destruct genes and produced more damaging oxygen molecules. Eftekhari Kenzerki sees the carrier as a way to strengthen an old therapy.
Catalog record
| CREATOR | Raheleh Eftekhari Kenzerki, Mehdi Karamian, Iraj Sharifi, Abbas Pardakhty, Hamidreza Kheiri, Ehsan Salarkia, Alireza Keyhani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |