Mesoporous catechin hydrogel for enhanced astaxanthin-based inflammatory bowel disease therapy
Ningli Guo, Jiayi Shi, Xinyu Zhang, Hui Xu, Tongyao Ji, Fengkai Qiu, Kai Li, Zhenyi Wu, Ji Ma, Qiaoyou Weng, Rongfang Qiu, Gaofeng Shu, Zhang Chen, Jingfeng Chen, Xiaojing Wang · 2026
Read Mesoporous catechin hydrogel for enhanced astaxanthin-based inflammatory bowel disease therapy by Ningli Guo, Jiayi Shi, Xinyu Zhang, Hui Xu, Tongyao Ji, Fengkai Qiu, Kai Li, Zhenyi Wu, Ji Ma, Qiaoyou Weng, Rongfang Qiu, Gaofeng Shu, Zhang Chen, Jingfeng Chen, Xiaojing Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13483827.txt.
Description
Ningli Guo designs a swallowable gel carrying a sea-derived antioxidant to calm inflammatory bowel disease. Published in 2026, the system loads astaxanthin, a red pigment with poor water solubility, into porous catechin particles, then suspends them in an alginate gel that lingers in the gut. Tests cover cell inflammation models and a chemical colitis model in mice.
Loaded particles beat either ingredient alone at clearing reactive oxygen and quieting inflammation in toxin-stimulated immune cells. The particles nudged those cells from an attacking state toward a calming state through a major inflammatory signaling route. In mice, oral gel eased clinical symptoms, restored gut barrier integrity, and rebalanced gut microbes toward greater diversity with fewer harmful species. Better delivery turned a poorly absorbed natural compound into a credible gut therapy candidate.
Catalog record
| CREATOR | Ningli Guo, Jiayi Shi, Xinyu Zhang, Hui Xu, Tongyao Ji, Fengkai Qiu, Kai Li, Zhenyi Wu, Ji Ma, Qiaoyou Weng, Rongfang Qiu, Gaofeng Shu, Zhang Chen, Jingfeng Chen, Xiaojing Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77531 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |