Integrative multi-omics analysis reveals host–microbiome metabolic alterations and candidate biomarkers in Parkinson’s disease
Qiang Zhao, Shujia Zuo, Sufang Liu, Juan Wang, Jie Tang, Xuanxuan Zou, Yahui Leng, Xianhong Li, Min Zhou, Jing Tian, Puqing Wang · 2026
Read Integrative multi-omics analysis reveals host–microbiome metabolic alterations and candidate biomarkers in Parkinson’s disease by Qiang Zhao, Shujia Zuo, Sufang Liu, Juan Wang, Jie Tang, Xuanxuan Zou, Yahui Leng, Xianhong Li, Min Zhou, Jing Tian, Puqing Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13483817.txt.
Description
Qiang Zhao and others combine gut microbe reading with blood chemistry to study Parkinson disease from both sides of the gut-brain link. In 2026, the study compares stool and plasma from thirty patients with thirty healthy spouse controls, using shotgun reading of germ DNA and untargeted analysis of plasma breakdown products. The aim is to connect germ shifts with changes in the body's fuel use.
Germ variety and composition differed clearly between groups, with several species shifted in patients and eighty-six plasma breakdown products altered, including fats, indoleacetic acid, and kynurenic acid. Pathway analysis tied germ functions to host energy changes, and machine-learning panels distinguished patients from controls with strong rightness in testing data. The work offers candidate markers and testable links between microbes and breakdown products for future research.
Catalog record
| CREATOR | Qiang Zhao, Shujia Zuo, Sufang Liu, Juan Wang, Jie Tang, Xuanxuan Zou, Yahui Leng, Xianhong Li, Min Zhou, Jing Tian, Puqing Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |