A CD54-targeted magneto-responsive nanotheranostic for precision treatment of viral pneumonia via CTSB-mediated PANoptosis inhibition
Jing Chen, Song-Lin Jiang, Ying-Jun Lou, Zhi-Min Rao, Chun-Li Cai, Fang Wu, Qian-Yun Zhang, Yan-Hui Qin, Karim Malik, Arman Chowdhury, Hua-Zhong Ying, Chen-Huan Yu · 2026
Read A CD54-targeted magneto-responsive nanotheranostic for precision treatment of viral pneumonia via CTSB-mediated PANoptosis inhibition by Jing Chen, Song-Lin Jiang, Ying-Jun Lou, Zhi-Min Rao, Chun-Li Cai, Fang Wu, Qian-Yun Zhang, Yan-Hui Qin, Karim Malik, Arman Chowdhury, Hua-Zhong Ying, Chen-Huan Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13483613.txt.
Description
Jing Chen and colleagues published a nanomedicine study in 2026. They built a magnetic particle to treat viral pneumonia. Broad treatments must block viruses and calm inflammation. Their particle carries a cathepsin B blocking drug. A targeting ring guides it to lung cells. Magnets can also steer it toward the lungs. The iron core doubles as an imaging agent. It also mops up harmful oxygen radicals directly. Mouse models of flu and coronavirus were treated.
The particle blocked entry of several respiratory viruses. Lung drug levels rose many-fold versus free drug. Cell death driven by inflammation was reduced clearly. MRI signal tracked pneumonia severity in real time. Treated mice had lower virus loads and inflammation. A related lung injury model also improved. The design joins diagnosis and therapy in one platform. Human safety remains to be tested separately.
Catalog record
| CREATOR | Jing Chen, Song-Lin Jiang, Ying-Jun Lou, Zhi-Min Rao, Chun-Li Cai, Fang Wu, Qian-Yun Zhang, Yan-Hui Qin, Karim Malik, Arman Chowdhury, Hua-Zhong Ying, Chen-Huan Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |