IDMME and IDMDE: inducible CRISPR-dCasRx platforms for spatiotemporal RNA m5C editing
Jinming Xu, Jiaju Xu, Congcong Cao, Yichang Shu, Letian Shen, Xuhong He, Qi Huangfu, Chengfang Sun, Weikai Wang, Jingchao Wei, Ming Cai, Bohan Wang, Aolin Li, Yuchen Liu, Jiaming Wen · 2026
Read IDMME and IDMDE: inducible CRISPR-dCasRx platforms for spatiotemporal RNA m5C editing by Jinming Xu, Jiaju Xu, Congcong Cao, Yichang Shu, Letian Shen, Xuhong He, Qi Huangfu, Chengfang Sun, Weikai Wang, Jingchao Wei, Ming Cai, Bohan Wang, Aolin Li, Yuchen Liu, Jiaming Wen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13483152.txt.
Description
Jinming Xu and co-authors present a 2026 pair of switchable tools for editing a chemical mark on RNA. The mark, a methyl tag on cytosine letters, shapes how messages behave and goes astray in cancers, yet older editors run always-on with no undo. Their systems split the editing enzyme and wake it only when a plant hormone signal arrives, using a tamed CRISPR guide that grips RNA without cutting it.
A light-caged form of the signal adds flash control, so edits can start at a chosen place and moment. In kidney cancer models, targeted edits changed how key transcripts worked and slowed tumour growth in dishes and in animals. Off-target edits stayed low. A reversible, timed editor lets researchers probe what each mark does and hints at RNA drugs that act only where switched on.
Catalog record
| CREATOR | Jinming Xu, Jiaju Xu, Congcong Cao, Yichang Shu, Letian Shen, Xuhong He, Qi Huangfu, Chengfang Sun, Weikai Wang, Jingchao Wei, Ming Cai, Bohan Wang, Aolin Li, Yuchen Liu, Jiaming Wen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74471 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |