Down-regulation of GPRC5A Confers Protection Against Periodontitis
Yuhan Hu, Runxuan Liu, Xinxiao Chen, Lingling Shang · 2026
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Description
Yuhan Hu and co-authors report a 2026 study of a receptor protein that fuels gum disease. Periodontitis rots the tissue and bone that hold teeth, driven by runaway inflammation. The receptor, called GPRC5A, ran high in inflamed human gum tissue. The team silenced it in mice with gum disease and in gum ligament cells stressed with bacterial toxin.
Silencing cut bone loss and disease severity in mice. In cells it lowered inflammatory output and calmed a master inflammation switch. A partner protein fell in step, and its own partner, a protein-building factor, carried less of an activating mark. The chain offers a fresh drug angle for gum disease, though the authors note that direct proof of the full chain still needs work.
Catalog record
| CREATOR | Yuhan Hu, Runxuan Liu, Xinxiao Chen, Lingling Shang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47354 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |