Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging
Mira Sleiman, Dimitra Ranti, Sudarson Baskaran, Patricia Kreis, Saskia Muth, Christian Gallrein, Agnieszka Münster-Wandowski, Norman Rahnis, Emilio Cirri, Britta J. Eickholt, Janine Kirstein · 2026
Read Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging by Mira Sleiman, Dimitra Ranti, Sudarson Baskaran, Patricia Kreis, Saskia Muth, Christian Gallrein, Agnieszka Münster-Wandowski, Norman Rahnis, Emilio Cirri, Britta J. Eickholt, Janine Kirstein (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13481654.txt.
Description
Proteostasis is essential for maintaining neuronal function, and its dysregulation is a hallmark of aging and neurodegeneration. The ubiquitin–proteasome system (UPS) and macroautophagy are the two major proteolytic pathways responsible for protein degradation. However, their capacity and regulation differ between cell types and across aging.
Catalog record
| CREATOR | Mira Sleiman, Dimitra Ranti, Sudarson Baskaran, Patricia Kreis, Saskia Muth, Christian Gallrein, Agnieszka Münster-Wandowski, Norman Rahnis, Emilio Cirri, Britta J. Eickholt, Janine Kirstein |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |