ASAP3 activates the NF-κB signaling pathway to promote the progression of esophageal squamous cell carcinoma
Jingyu Liu, Chenlu Dai, Li Liu, Min Ji, Gulirena Mijiti, Mengjie Zhuang, Sensen Zhu, Ming Cheng, Xuanming Liu, Linlin Zhang, Wei Zhang, Liping Su, Hongwei Pu · 2026
Read ASAP3 activates the NF-κB signaling pathway to promote the progression of esophageal squamous cell carcinoma by Jingyu Liu, Chenlu Dai, Li Liu, Min Ji, Gulirena Mijiti, Mengjie Zhuang, Sensen Zhu, Ming Cheng, Xuanming Liu, Linlin Zhang, Wei Zhang, Liping Su, Hongwei Pu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13481611.txt.
Description
Jingyu Liu and co-authors describe a 2026 study of a protein called ASAP3 in cancer of the food pipe. This cancer type kills many patients and lacks good drug targets. The team stained tumour samples for ASAP3 plus four partner proteins and charted links to patient traits and survival.
High levels of all five proteins tracked with poor outlook. In cell work, silencing ASAP3 slowed growth, movement, and invasion of cancer cells. In mice, silenced tumours grew smaller with lower growth activity. Tracing the chain showed ASAP3 works through a partner called NEMO to switch on a master inflammation pathway, which then drives spread traits. The authors pitch ASAP3 as both a warning marker and a drug target worth testing in this cancer.
Catalog record
| CREATOR | Jingyu Liu, Chenlu Dai, Li Liu, Min Ji, Gulirena Mijiti, Mengjie Zhuang, Sensen Zhu, Ming Cheng, Xuanming Liu, Linlin Zhang, Wei Zhang, Liping Su, Hongwei Pu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37876 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |