Mechanisms of weight gain associated with valproic acid: a scoping review
Darja Popkova, Frederike Fellendorf, Maj Vinberg, Deniz Ceylan, Aija Bukova-Zideluna, Eva Fleischmann, Nina Dalkner, Adelina Tmava-Berisha, Melanie Lenger, Mirko Manchia, Eva Reininghaus · 2026
Read Mechanisms of weight gain associated with valproic acid: a scoping review by Darja Popkova, Frederike Fellendorf, Maj Vinberg, Deniz Ceylan, Aija Bukova-Zideluna, Eva Fleischmann, Nina Dalkner, Adelina Tmava-Berisha, Melanie Lenger, Mirko Manchia, Eva Reininghaus (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13481424.txt.
Description
Darja Popkova and co-authors offer a 2026 scoping review of why valproic acid, a mainstay drug for seizures and mood care, so often adds weight. The team searched four databases and mapped fifteen studies with 1,339 adults in total. Study types ranged from snapshots and follow-ups to gene studies, and quality checks used a standard scale.
Proof clustered into three lanes. Hormone shifts led, covering raised insulin, raised leptin, and insulin resistance. Fat measures shifted too, with higher total cholesterol and triglycerides plus mixed readings for protective cholesterol. Gene lanes stayed young, pointing to a drug-processing gene variant and a methylation mark, yet small groups demand larger checks. Bipolar patients were scarce in the pool. The map argues for personal watch plans that track weight, hormones, and lipids from the start.
Catalog record
| CREATOR | Darja Popkova, Frederike Fellendorf, Maj Vinberg, Deniz Ceylan, Aija Bukova-Zideluna, Eva Fleischmann, Nina Dalkner, Adelina Tmava-Berisha, Melanie Lenger, Mirko Manchia, Eva Reininghaus |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35740 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |