The deSUMOylase SPF2 and the cohesin regulators SGO2 and CTF18 suppress crossovers near centromeres
Rigel Salinas Gamboa, Joiselle Blanche Fernandes, Qichao Lian, Dipesh Kumar Singh, Stephanie Durand, Divyanshu Sahu, Laia Capilla-Perez, Hernan Lopez, Alexandra Kalde, Raphael Mercier · 2026
Read The deSUMOylase SPF2 and the cohesin regulators SGO2 and CTF18 suppress crossovers near centromeres by Rigel Salinas Gamboa, Joiselle Blanche Fernandes, Qichao Lian, Dipesh Kumar Singh, Stephanie Durand, Divyanshu Sahu, Laia Capilla-Perez, Hernan Lopez, Alexandra Kalde, Raphael Mercier (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13481266.txt.
Description
Rigel Salinas Gamboa and co-authors describe a 2026 gene hunt for what keeps chromosome swaps away from centromeres in a model plant. Swaps near the chromosome centre are shut off in nearly all species, which blocks breeders from moving prized genes parked there. Working in Arabidopsis, the team found three guards: a protein that trims a small tag, a protector of the glue that holds chromosome copies, and a loader of that glue.
Knocking out any guard let swaps appear where none formed before and boosted swaps where they were rare. Stacking the faults, or adding a fault in a DNA marking enzyme, pushed counts higher still, which shows several brakes act in parallel. Glue turnover near the centre seems central to the shut-off. Breeders may one day lift the brake briefly to unlock genes near centromeres.
Catalog record
| CREATOR | Rigel Salinas Gamboa, Joiselle Blanche Fernandes, Qichao Lian, Dipesh Kumar Singh, Stephanie Durand, Divyanshu Sahu, Laia Capilla-Perez, Hernan Lopez, Alexandra Kalde, Raphael Mercier |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75271 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |