Multifactorial hypophosphatemia: a diagnostic challenge involving denosumab, iron infusion, renal tubular acidosis, and gastrointestinal losses
Liam Clifford, Tripti Joshi · 2026
Read Multifactorial hypophosphatemia: a diagnostic challenge involving denosumab, iron infusion, renal tubular acidosis, and gastrointestinal losses by Liam Clifford, Tripti Joshi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13481143.txt.
Description
Liam Clifford and Tripti Joshi describe a 2026 case where many small causes stacked into severe phosphate loss. A 39-year-old woman with a kidney transplant, bowel disease with past resections, and thin bones arrived with belly pain, nausea, and constipation. Blood tests showed phosphate at a fraction of normal, plus low calcium and potassium.
Recent iron infusions and a bone drug both drive kidney phosphate wasting through a hormone signal. Kidney tube acid trouble, an overactive parathyroid state, her anti-rejection drug, and gut losses from a blocked bowel each added drain. Heavy replacement failed to hold levels until the anti-rejection dose fell and acid balance improved, yet relapses followed across repeat admissions. The case urges joint specialty review and long watch after iron and bone drugs in fragile patients.
Catalog record
| CREATOR | Liam Clifford, Tripti Joshi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |