Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery
Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou, Christoph Rademacher · 2026
Read Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery by Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou, Christoph Rademacher (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13480715.txt.
Description
Sebastian Bayer and co-authors describe a 2026 delivery trick that aims RNA cargo at tumour blood vessels through a side door. Vessels feeding tumours carry extra copies of a grip protein, yet standard grip mimics also stick to cousins of that protein. The team fished for weak binders at a second site while the main site stayed blocked, then arrayed many copies on fat particles to build grip by numbers.
Uptake in model cells and in human vein cells rose with copy number in a sharp, switch-like curve, sparing cells with few targets. Standard mimic particles showed no such switch. RNA sent by the aimed particles produced six times more working protein than un-aimed controls. Weak-but-many binding may pick out high-target cells more cleanly than one strong grip.
Catalog record
| CREATOR | Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou, Christoph Rademacher |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25824 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |