Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables Remote‐Markovnikov Hydroamination of Alkenes
Arman Khosravi, Ho Martin Yuen, Seth Fremin, Nuwan A. Pannilawithana, Nol Supasueb, Yu Zhang, Peng Liu, Ming‐Yu Ngai · 2026
Read Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables Remote‐Markovnikov Hydroamination of Alkenes by Arman Khosravi, Ho Martin Yuen, Seth Fremin, Nuwan A. Pannilawithana, Nol Supasueb, Yu Zhang, Peng Liu, Ming‐Yu Ngai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13480516.txt.
Description
Arman Khosravi and co-authors describe a 2026 reaction that plants nitrogen three atoms away from a carbon double bond. Amino alcohols built this way serve drug and farm chemistry, yet most methods add nitrogen right at the bond itself. The team combined light-driven catalysis, a cobalt catalyst, and an acid helper to move the action down the chain.
First a metal hydride hands a hydrogen atom to the bond, then an ester group hops one atom over, which parks a reactive radical at the far site. Evidence from bench work and modelling favours a cobalt-to-carbon handoff of nitrogen, a rare step, over charged or high-state detours. The route delivered shielded amino alcohols across many starting chains, with some control over shape at the new centre. Remote placement widens the map of amino alcohols open to makers.
Catalog record
| CREATOR | Arman Khosravi, Ho Martin Yuen, Seth Fremin, Nuwan A. Pannilawithana, Nol Supasueb, Yu Zhang, Peng Liu, Ming‐Yu Ngai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20910 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |