Fisetin Attenuates Amyloid‐Beta‐Induced Neurotoxicity in Human Neuroblastoma SH‐SY5Y Cells: Integrating In Silico Target Prediction and In Vitro Validation
Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh · 2026
Read Fisetin Attenuates Amyloid‐Beta‐Induced Neurotoxicity in Human Neuroblastoma SH‐SY5Y Cells: Integrating In Silico Target Prediction and In Vitro Validation by Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13480354.txt.
Description
Charu Jaiswal, Ishika Singh, and Abhishek Kumar Singh test a plant compound against Alzheimer's-like harm in a 2026 study. Fisetin, a natural flavonoid in many fruits, fights oxidation, but its brain protection was unclear. Amyloid beta, the sticky protein of the disease, harms nerve cells.
Computer models showed fisetin binding stably to three brain health proteins, at the same spots amyloid beta targets. In human nerve-like cells poisoned with amyloid beta, fisetin raised survival. It cut oxidative stress and restored ion channel activity that the toxin had dulled. It also boosted antioxidant defenses and signs of the cell's recycling system. The combined evidence marks fisetin as a multi-target protector.
Catalog record
| CREATOR | Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |