Design of M13 phage systems dual-displaying two functional proteins for developing a rapid biosensing probe
Qiang Meng, Huimin Zhang, Ting Liu, Ziyue Yuan, Meiling Guo, Wei Song, Qinglin Sheng, Yane Luo, Tianli Yue · 2026
Read Design of M13 phage systems dual-displaying two functional proteins for developing a rapid biosensing probe by Qiang Meng, Huimin Zhang, Ting Liu, Ziyue Yuan, Meiling Guo, Wei Song, Qinglin Sheng, Yane Luo, Tianli Yue (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13480030.txt.
Description
Qiang Meng and colleagues engineered virus-based probes that display two working proteins at once in 2026. M13 phage particles can carry both a targeting part and a reporter part, a promising recipe for fast sensors. Which display sites combine best was poorly known, so combinations were tested systematically using a binder aimed at a seafood-borne bacterium.
One display pairing kept good activity and gave the highest share of doubly functional particles. The tuned probe detected the target bacterium in spiked shrimp samples with high specificity, sensitivity, and resistance to interference. The authors offer the work as a practical framework for building one-step phage sensors for other targets.
Catalog record
| CREATOR | Qiang Meng, Huimin Zhang, Ting Liu, Ziyue Yuan, Meiling Guo, Wei Song, Qinglin Sheng, Yane Luo, Tianli Yue |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |