Anti-miR-195-engineered mesenchymal stem cells promote migration, vascularization, and ECM protein expression in vivo
Sara Reis Moura, Mafalda Montenegro Cortez, Isabel Brandão, Inês Alencastre, Susana Gomes Santos, Carla Cunha, Maria Inês Almeida · 2026
Read Anti-miR-195-engineered mesenchymal stem cells promote migration, vascularization, and ECM protein expression in vivo by Sara Reis Moura, Mafalda Montenegro Cortez, Isabel Brandão, Inês Alencastre, Susana Gomes Santos, Carla Cunha, Maria Inês Almeida (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13479702.txt.
Description
Sara Moura and six co-authors engineer stem cells to heal bone better by blocking one small gene regulator, miR-195. Their 2026 study works with mesenchymal stem cells, repair cells used in advanced therapies whose results in patients have been uneven. Turning their healing power up is the goal.
Cells treated with the blocker showed gene patterns tied to movement, growth, and less cell aging, plus more of a bone density marker. Seeded on scaffolds and placed in mice, the cells spread faster than untreated ones. By four weeks the scaffolds held more collagen, more bone markers, and more and larger blood vessels. The authors back microRNA tuning as a way to strengthen cell therapies for bone defects.
Catalog record
| CREATOR | Sara Reis Moura, Mafalda Montenegro Cortez, Isabel Brandão, Inês Alencastre, Susana Gomes Santos, Carla Cunha, Maria Inês Almeida |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |