Microstructural MRI combined with metabolic MRI to evaluate the progression-free survival of patients with glioblastoma at the early follow-up after tumor treating fields: a pilot study
Jue Lu, XinLi Zhang, Xiaotong Guo, Qian Qin, Jiaqi Chen, Peng Sun, Jing Wang · 2026
Read Microstructural MRI combined with metabolic MRI to evaluate the progression-free survival of patients with glioblastoma at the early follow-up after tumor treating fields: a pilot study by Jue Lu, XinLi Zhang, Xiaotong Guo, Qian Qin, Jiaqi Chen, Peng Sun, Jing Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13479546.txt.
Description
Jue Lu and colleagues report a 2026 pilot imaging study in glioblastoma, the most aggressive brain tumor, for patients receiving tumor treating fields therapy. Judging early whether this electrical field treatment works is difficult with standard scans. The team combined time-dependent diffusion imaging, which infers cell size and density, with metabolic imaging sensitive to protein content.
Patients were scanned before treatment and again one to six months into tumor treating fields or temozolomide chemotherapy, between May 2023 and November 2024. Computed measures included estimated cell diameter, intracellular volume fraction, cellularity, and outside-cell water movement. The study tests whether these microstructural and metabolic signals track with progression-free survival. As a pilot, its job is to show feasibility and point to which measures deserve a larger trial.
Catalog record
| CREATOR | Jue Lu, XinLi Zhang, Xiaotong Guo, Qian Qin, Jiaqi Chen, Peng Sun, Jing Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44095 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |