Temporal dynamics of substance P and its association with cytokine release syndrome after CD19 CAR-T therapy in pediatric B-ALL
Águeda Molinos-Quintana, Alfonso Rodríguez-Gil, Teresa Caballero-Velázquez, Estefanía García-Guerrero, Patricia Alcalde-Mellado, Paola Hernández-Díaz, Javier Delgado-Serrano, Victoria Ruiz-Maldonado, Raquel Muñoz-García, Juan Luis Reguera-Ortega, Elia Sánchez-Valderrábanos, José Antonio Pérez-Simón · 2026
Read Temporal dynamics of substance P and its association with cytokine release syndrome after CD19 CAR-T therapy in pediatric B-ALL by Águeda Molinos-Quintana, Alfonso Rodríguez-Gil, Teresa Caballero-Velázquez, Estefanía García-Guerrero, Patricia Alcalde-Mellado, Paola Hernández-Díaz, Javier Delgado-Serrano, Victoria Ruiz-Maldonado, Raquel Muñoz-García, Juan Luis Reguera-Ortega, Elia Sánchez-Valderrábanos, José Antonio Pérez-Simón (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13479545.txt.
Description
Águeda Molinos-Quintana and coauthors published a 2026 study tracking substance P, a nerve signaling molecule, during cytokine release syndrome after CAR-T cell therapy in children with leukemia. This inflammatory storm is the therapy's main toxicity, yet nerve-immune signals inside it were unexplored. Blood samples came from eighteen young patients with relapsed or resistant B-cell leukemia treated with tisagenlecleucel.
Substance P was measured before treatment and on days seven, fourteen, and twenty-eight, with extra draws during storm episodes when possible. The analysis follows how the molecule rises and falls against the timing and severity of the syndrome. Understanding neuropeptide behavior could reveal new ways to predict or calm this dangerous reaction. The work is set in real-world clinical care rather than a controlled trial.
Catalog record
| CREATOR | Águeda Molinos-Quintana, Alfonso Rodríguez-Gil, Teresa Caballero-Velázquez, Estefanía García-Guerrero, Patricia Alcalde-Mellado, Paola Hernández-Díaz, Javier Delgado-Serrano, Victoria Ruiz-Maldonado, Raquel Muñoz-García, Juan Luis Reguera-Ortega, Elia Sánchez-Valderrábanos, José Antonio Pérez-Simón |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28890 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |