Network pharmacology and experimental evaluation of Sanwei Tanxiang Tangsan in doxorubicin-induced heart failure
Aruna, Dulan, Davaadagva Damdinjav, Battulga Tungalag, GuiZhi, Hua Li · 2026
Read Network pharmacology and experimental evaluation of Sanwei Tanxiang Tangsan in doxorubicin-induced heart failure by Aruna, Dulan, Davaadagva Damdinjav, Battulga Tungalag, GuiZhi, Hua Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13479448.txt.
Description
Aruna and coauthors published a 2026 study of Sanwei Tanxiang Tangsan, a Mongolian herbal formula, in heart failure caused by the chemotherapy drug doxorubicin. Heart failure involves inflammation, oxidative stress, and heart cell death, and tolerated treatments remain limited. The team combined network pharmacology, molecular docking, and rat experiments.
Computer screening first mapped the formula's active ingredients onto disease targets and flagged a pathway involving AKT1 and p53. Rats with drug-induced heart failure then received the formula by stomach tube for four weeks, with a modern heart drug as positive control. Heart function measures and tissue levels of AKT1, interleukin-6, and p53 were compared across groups. The design tests whether a traditional formula acts through the predicted signaling route.
Catalog record
| CREATOR | Aruna, Dulan, Davaadagva Damdinjav, Battulga Tungalag, GuiZhi, Hua Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47157 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |