Data quality biases normative models derived from fetal brain MRI
Thomas Sanchez, Angeline Mihailov, Gerard Martí-Juan, Nadine Girard, Aurélie Manchon, Mathieu Milh, Elisenda Eixarch, Vincent Dunet, Mériam Koob, Léo Pomar, Joanna Sichitiu, Miguel A. González Ballester, Oscar Camara, Gemma Piella, Meritxell Bach Cuadra, Guillaume Auzias · 2026
Read Data quality biases normative models derived from fetal brain MRI by Thomas Sanchez, Angeline Mihailov, Gerard Martí-Juan, Nadine Girard, Aurélie Manchon, Mathieu Milh, Elisenda Eixarch, Vincent Dunet, Mériam Koob, Léo Pomar, Joanna Sichitiu, Miguel A. González Ballester, Oscar Camara, Gemma Piella, Meritxell Bach Cuadra, Guillaume Auzias (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13479347.txt.
Description
Thomas Sanchez and fourteen co-authors show that scan quality biases growth models built from fetal brain MRI, in a study from 2026. Normative models chart typical growth and flag atypical development before birth. Scanning a moving fetus makes image quality uneven, and larger samples are often prized over cleaner ones.
Using 635 scans from several centers with a standard quality rating, they fit growth models under looser and stricter quality cuts. Adding lower-quality scans shifted growth centiles in a systematic way, most at the lowest tail. Bias grew as standards relaxed and varied by brain structure, even when segmentations looked fine.
Catalog record
| CREATOR | Thomas Sanchez, Angeline Mihailov, Gerard Martí-Juan, Nadine Girard, Aurélie Manchon, Mathieu Milh, Elisenda Eixarch, Vincent Dunet, Mériam Koob, Léo Pomar, Joanna Sichitiu, Miguel A. González Ballester, Oscar Camara, Gemma Piella, Meritxell Bach Cuadra, Guillaume Auzias |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |