An ANGPTL8‐AKT2‐mTOR Axis Drives Adipose Senescence and Aging‐Related Functional Decline
Yi He, Limeng Pan, WenJun Ping, Chen Meng, Xiaoyu Meng, Yaming Guo, Ranran Kan, Yuxi Xiang, Beibei Mao, Siyi Wang, Danpei Li, Xuefeng Yu · 2026
Read An ANGPTL8‐AKT2‐mTOR Axis Drives Adipose Senescence and Aging‐Related Functional Decline by Yi He, Limeng Pan, WenJun Ping, Chen Meng, Xiaoyu Meng, Yaming Guo, Ranran Kan, Yuxi Xiang, Beibei Mao, Siyi Wang, Danpei Li, Xuefeng Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13478719.txt.
Description
He and a team in China pinned in 2026 a blood factor that seems to drive fat tissue to age fast, and the body with it. The factor, ANGPTL8, was known for its hand in fat and sugar traffic. In a large group of adults, high blood levels of it tracked with faster body ageing and a higher risk of death. It even sharpened machine built age and death forecasts. The team then bred mice that lacked the factor's gene.
Those mice lived longer, kept their strength and skill with age, and showed fewer worn out cells in their fat. In fat cells, the factor had risen with age and switched on age linked gene sets. Tests showed it grips a cell switch called AKT2 and fires a growth path that pushes cells into worn out rest. Drugs or gene cuts that blocked that path wiped out the push.
Catalog record
| CREATOR | Yi He, Limeng Pan, WenJun Ping, Chen Meng, Xiaoyu Meng, Yaming Guo, Ranran Kan, Yuxi Xiang, Beibei Mao, Siyi Wang, Danpei Li, Xuefeng Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 123 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |