Dual actionability of BMI1 activation and mitotic vulnerability defines adaptive Osimertinib resistance in EGFR-mutant NSCLC
Paolo Armanetti, Eva Cabrera San Millan, Maddalena Di Nardo, Raffaella Mercatelli, Chiara Cavallini, Stefania Crucitta, Marzia Del Re, Alice Chiodi, Ettore Mosca, Arianna Consiglio, Nicola Losito, Antonio Musio, Luca Menichetti, Emilia Bramanti, Azhar Ali, Elena Levantini, Giorgia Maroni · 2026
Read Dual actionability of BMI1 activation and mitotic vulnerability defines adaptive Osimertinib resistance in EGFR-mutant NSCLC by Paolo Armanetti, Eva Cabrera San Millan, Maddalena Di Nardo, Raffaella Mercatelli, Chiara Cavallini, Stefania Crucitta, Marzia Del Re, Alice Chiodi, Ettore Mosca, Arianna Consiglio, Nicola Losito, Antonio Musio, Luca Menichetti, Emilia Bramanti, Azhar Ali, Elena Levantini, Giorgia Maroni (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13478582.txt.
Description
Paolo Armanetti and colleagues present a 2026 study of how lung tumors with EGFR mutations adapt to the targeted drug osimertinib. Such tumors first shrink on the drug, yet resistance always emerges, often through flexible non-genetic changes. Resistant H1975 cells in the lab grew more migratory and aggressive than their parent cells.
Profiling showed resistant cells switching on target genes of BMI1, a stemness regulator, alongside faulty cell division and frequent cytokinesis errors. Forcing BMI1 up in parent cells recreated both resistance and migration, marking it as a central driver. The same division defects created a weakness: a tubulin-binding compound that also blocks BMI1 attacked the resistant cells through their dependence on division machinery. The authors frame resistance itself as a source of drug targets.
Catalog record
| CREATOR | Paolo Armanetti, Eva Cabrera San Millan, Maddalena Di Nardo, Raffaella Mercatelli, Chiara Cavallini, Stefania Crucitta, Marzia Del Re, Alice Chiodi, Ettore Mosca, Arianna Consiglio, Nicola Losito, Antonio Musio, Luca Menichetti, Emilia Bramanti, Azhar Ali, Elena Levantini, Giorgia Maroni |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44955 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |