Insulin resistance drives GGT elevation in MASLD with diabetes: evidence from clinical cohorts, mendelian randomization and functional genomics
Ayan Mandal, Ankita Chatterjee, Debopriyo Ganguly, Bandana Mondal, Analabha Basu, Priyadarshi Basu · 2026
Read Insulin resistance drives GGT elevation in MASLD with diabetes: evidence from clinical cohorts, mendelian randomization and functional genomics by Ayan Mandal, Ankita Chatterjee, Debopriyo Ganguly, Bandana Mondal, Analabha Basu, Priyadarshi Basu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13478528.txt.
Description
Ayan Mandal and coauthors published a 2026 study asking why the liver enzyme GGT rises in fatty liver disease combined with type 2 diabetes. The two conditions often coexist through insulin resistance, yet GGT gets less attention than other liver enzymes. The team combined a hospital cohort of 498 patients with validation in a United States survey dataset of 2,586 people.
Patients with both conditions had the highest GGT and insulin resistance scores. Genetic analyses using Mendelian randomization pointed to a causal push from genetically higher fasting insulin toward higher GGT, separate from other metabolic traits. Functional mapping of GGT-linked gene variants added biological context. The authors conclude that insulin resistance itself drives much of the enzyme elevation, which may sharpen how clinicians read this routine test.
Catalog record
| CREATOR | Ayan Mandal, Ankita Chatterjee, Debopriyo Ganguly, Bandana Mondal, Analabha Basu, Priyadarshi Basu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48648 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |