NAT10 inhibition alleviates renal tubular epithelial cell senescence by impeding ac4C acetylation of PAPP-A mRNA in diabetic nephropathy
Mingyang Hu, Linxiao Lv, Ruxu Li, Zihao Zhao, Wenxin Li, Yanyan Wang, Zhangsuo Liu, Yanfang Lu, Sijie Zhou · 2026
Read NAT10 inhibition alleviates renal tubular epithelial cell senescence by impeding ac4C acetylation of PAPP-A mRNA in diabetic nephropathy by Mingyang Hu, Linxiao Lv, Ruxu Li, Zihao Zhao, Wenxin Li, Yanyan Wang, Zhangsuo Liu, Yanfang Lu, Sijie Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13478519.txt.
Description
Mingyang Hu and colleagues report a 2026 study of NAT10, an enzyme that adds a chemical mark to RNA, in diabetic kidney disease. Cell aging in the kidney's tubules helps drive this common diabetes complication. Patient kidney tissue showed markedly higher NAT10 levels, and higher levels tracked with worse clinical outcomes.
The enzyme attached its ac4C mark to the RNA of PAPP-A, a growth-related protein, making that RNA last longer and produce more protein. Through a pathway involving p53, this pushed tubule cells into senescence. Deleting or silencing NAT10 in two mouse diabetes models eased tubule aging, and a drug blocker called Remodelin protected cells in animals and dishes alike. The authors nominate this axis as a treatment target.
Catalog record
| CREATOR | Mingyang Hu, Linxiao Lv, Ruxu Li, Zihao Zhao, Wenxin Li, Yanyan Wang, Zhangsuo Liu, Yanfang Lu, Sijie Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54483 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |