A labile sulfur ligand in a three-cysteine-coordinated [2Fe−2S] cluster mediates sulfide sensing in NreB
Chao Tang, Yuemeng Shen, Jingyao Qu, Lu Yu, Honglei Liu, Huaiwei Liu, Luying Xun, Yongzhen Xia · 2026
Read A labile sulfur ligand in a three-cysteine-coordinated [2Fe−2S] cluster mediates sulfide sensing in NreB by Chao Tang, Yuemeng Shen, Jingyao Qu, Lu Yu, Honglei Liu, Huaiwei Liu, Luying Xun, Yongzhen Xia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13478379.txt.
Description
Chao Tang and seven colleagues revealed in 2026 how bacteria sense sulfide through an unusual iron-sulfur cluster in the sensor kinase NreB. Iron-sulfur clusters serve many roles, but their part in sulfide sensing was largely unexplored.
A high-resolution crystal structure showed three cysteine residues plus a loose sulfur ligand holding the cluster in the sensor's PAS domain. Sulfide exposure enriched a modified ligand state and raised kinase activity, while the cluster stayed oxidised. Simulations showed transient access routes for sulfide to the buried cluster. Bacteria thus sense sulfide through a three-cysteine cluster with a labile sulfur ligand.
Catalog record
| CREATOR | Chao Tang, Yuemeng Shen, Jingyao Qu, Lu Yu, Honglei Liu, Huaiwei Liu, Luying Xun, Yongzhen Xia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |