An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing
Benjamin O Murray, Jinhui Gao, Laia Pasquina-Lemonche, Katherine Swarbrick, Guy Simpson, Mark A Chambers, Hardev Pandha, Alex Freeman, Jennifer L Rohn · 2026
Read An advanced in vitro bladder cancer model integrating bladder cancer spheroids into a healthy human urothelium for preclinical therapeutic testing by Benjamin O Murray, Jinhui Gao, Laia Pasquina-Lemonche, Katherine Swarbrick, Guy Simpson, Mark A Chambers, Hardev Pandha, Alex Freeman, Jennifer L Rohn (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13478310.txt.
Description
Benjamin O Murray and eight colleagues built in 2026 a lab model of bladder cancer that embeds tumour spheroids into healthy human bladder lining. Better models are needed for hard-to-treat bladder cancer, where outcomes have barely improved in decades.
The model, called 3D-UHU-TU, used low- and high-grade cell lines and showed correct marker expression plus invasion and migration behaviour. Standard chemotherapy damaged cancer spheroids while sparing healthy lining, and an oncolytic herpes virus likewise targeted cancer cells while sparing healthy tissue. The model serves safety and efficacy testing across grades, with patient spheroids a future step toward personalised testing.
Catalog record
| CREATOR | Benjamin O Murray, Jinhui Gao, Laia Pasquina-Lemonche, Katherine Swarbrick, Guy Simpson, Mark A Chambers, Hardev Pandha, Alex Freeman, Jennifer L Rohn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |