Divergent transcriptomic pathways underlie sex-biased cognitive rescue by developmental GSK3B inhibition in a mouse model of 22q11.2 deletion syndrome
Johannes Passecker, Chia-Yuan Chang, Aleksandra Dagunts, Chloe M. Aloimonos, Lukas Leitner, Arsenii Petryk, Florence F. Wagner, Maxym V. Myroshnychenko, David A. Kupferschmidt, Joseph A. Gogos, Joshua A. Gordon · 2026
Read Divergent transcriptomic pathways underlie sex-biased cognitive rescue by developmental GSK3B inhibition in a mouse model of 22q11.2 deletion syndrome by Johannes Passecker, Chia-Yuan Chang, Aleksandra Dagunts, Chloe M. Aloimonos, Lukas Leitner, Arsenii Petryk, Florence F. Wagner, Maxym V. Myroshnychenko, David A. Kupferschmidt, Joseph A. Gogos, Joshua A. Gordon (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13478295.txt.
Description
Johannes Passecker and colleagues report a 2026 mouse study on sex differences in a candidate treatment for 22q11.2 deletion syndrome, a genetic condition with high schizophrenia risk. The team gave a selective blocker of the enzyme GSK3B during development to mice carrying the deletion model. Working memory and brain rhythm coordination between prefrontal cortex and hippocampus were measured in adults.
The blocker rescued working memory in male mutant mice and improved rhythm synchrony, yet it gave no benefit to female mutants and even harmed normal females. Gene profiling of young prefrontal cortex showed the deletion shifted GSK3B-related expression in opposite directions by sex, raised in males and lowered in females. The authors argue that treatment development for this syndrome must account for sex from the start.
Catalog record
| CREATOR | Johannes Passecker, Chia-Yuan Chang, Aleksandra Dagunts, Chloe M. Aloimonos, Lukas Leitner, Arsenii Petryk, Florence F. Wagner, Maxym V. Myroshnychenko, David A. Kupferschmidt, Joseph A. Gogos, Joshua A. Gordon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76889 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |