Mitochondrial protein COXFA4L3 (C15ORF48) confers resistance to DNA-damaging anticancer agents by repressing mitochondrial DNA damage responses
Yuki Takakura, Seika Kawamura, Yui Hashiguchi, Manami Yamanaka, Yasuyuki Kurihara, Taishin Akiyama, Hiroyuki Takano, Noritaka Yamaguchi · 2026
Read Mitochondrial protein COXFA4L3 (C15ORF48) confers resistance to DNA-damaging anticancer agents by repressing mitochondrial DNA damage responses by Yuki Takakura, Seika Kawamura, Yui Hashiguchi, Manami Yamanaka, Yasuyuki Kurihara, Taishin Akiyama, Hiroyuki Takano, Noritaka Yamaguchi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13478198.txt.
Description
Yuki Takakura and seven colleagues showed in 2026 how a small mitochondrial protein helps cancer cells resist DNA-damaging chemotherapy. Such drugs kill fast-dividing cells by breaking DNA, yet acquired resistance limits them, and the mitochondrial side of resistance was little known.
The protein COXFA4L3, formerly C15ORF48, blocks mitochondrial DNA damage and pore opening, stopping damaged mitochondrial DNA from leaking into the cell interior. That leak would otherwise trigger the cGAS-STING immune alarm and cell death. By repressing this damage response, the protein confers resistance. The findings point to mitochondria as a lever for restoring chemosensitivity.
Catalog record
| CREATOR | Yuki Takakura, Seika Kawamura, Yui Hashiguchi, Manami Yamanaka, Yasuyuki Kurihara, Taishin Akiyama, Hiroyuki Takano, Noritaka Yamaguchi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |