Integration of bulk and single-cell RNA-seq data identifies a cellular senescence-related prognostic signature in liver hepatocellular carcinoma
Rentong Liu, Bing Li, Yiqian Luo, Xiuwei Yan, Yuanyuan Wang, Song Jiang, Chengjie Gan, Yiwei Cheng · 2026
Read Integration of bulk and single-cell RNA-seq data identifies a cellular senescence-related prognostic signature in liver hepatocellular carcinoma by Rentong Liu, Bing Li, Yiqian Luo, Xiuwei Yan, Yuanyuan Wang, Song Jiang, Chengjie Gan, Yiwei Cheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13478048.txt.
Description
Rentong Liu and coauthors published a 2026 study building a prognosis score for liver cancer from genes tied to cellular senescence, the state where cells stop dividing. Senescent cells can block tumors early yet later feed growth through inflammatory secretions. The team combined bulk and single-cell gene data from three large cancer collections.
From 167 senescence genes, fifteen carried prognostic weight and split patients into two types. One type shut immune cells out and fared poorly, while the other had few immune cells present at all. A risk score built from the genes predicted survival independently across cohorts. Single-cell data singled out EEF1E1 in malignant liver cells, and silencing that gene in experiments slowed cancer cell migration and invasion.
Catalog record
| CREATOR | Rentong Liu, Bing Li, Yiqian Luo, Xiuwei Yan, Yuanyuan Wang, Song Jiang, Chengjie Gan, Yiwei Cheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45667 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |