Multiomic Reference Map of Endothelial Mechanosensitive Pathways Under Athero‐ and Erosion‐Prone Flow
Giulio Vidotto, Sara Luzzi, Jonathan D Humphries, Robert Beal, David G McVey, Christopher P Nelson, Thomas R Webb, Martin J Humphries, Graham R Smith, Stephen J White · 2026
Read Multiomic Reference Map of Endothelial Mechanosensitive Pathways Under Athero‐ and Erosion‐Prone Flow by Giulio Vidotto, Sara Luzzi, Jonathan D Humphries, Robert Beal, David G McVey, Christopher P Nelson, Thomas R Webb, Martin J Humphries, Graham R Smith, Stephen J White (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13477354.txt.
Description
Giulio Vidotto and coauthors published a 2026 laboratory study mapping how coronary artery lining cells respond to different blood flow patterns. Plaque tends to grow where flow is disturbed, while surface erosion happens where flow runs high. The team grew human coronary endothelial cells for 72 hours under swirling flow, steady normal flow, and elevated flow, then measured gene, microRNA, and protein activity.
Elevated flow switched on a distinct program, with 665 genes responding only to that condition. Flow also changed which gene versions cells used, touching pathways tied to artery disease. Many flow-sensitive genes sat near known disease-linked DNA variants. Protein changes often failed to match gene changes, which the authors flag as a warning against reading gene data alone.
Catalog record
| CREATOR | Giulio Vidotto, Sara Luzzi, Jonathan D Humphries, Robert Beal, David G McVey, Christopher P Nelson, Thomas R Webb, Martin J Humphries, Graham R Smith, Stephen J White |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49975 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |