d-serine as a metabolic immune checkpoint in the tumour microenvironment
Kai Tsugaru, Shohei Suzuki, Kentaro Miyamoto, Kazuhiro Murakami, Akihiko Chida, Chihiro Kato, Naoto Fukasawa, Arina Shigehara, Mai Hasegawa, Yusuke Yoshimatsu, Jumpei Sasabe, Masashi Mita, Nick Barker, Yosuke Harada, Yasutaka Sukawa, Toshiaki Teratani, Nobuhiro Nakamoto, Hirofumi Kawakubo, Kaoru Takabayashi, Motohiko Kato, Naohisa Yahagi, Taisuke Kondo, Eri Arai, Yuko Kitagawa, Kenro Hirata, Yasuo Hamamoto, Takanori Kanai, Tomohisa Sujino · 2026
Read d-serine as a metabolic immune checkpoint in the tumour microenvironment by Kai Tsugaru, Shohei Suzuki, Kentaro Miyamoto, Kazuhiro Murakami, Akihiko Chida, Chihiro Kato, Naoto Fukasawa, Arina Shigehara, Mai Hasegawa, Yusuke Yoshimatsu, Jumpei Sasabe, Masashi Mita, Nick Barker, Yosuke Harada, Yasutaka Sukawa, Toshiaki Teratani, Nobuhiro Nakamoto, Hirofumi Kawakubo, Kaoru Takabayashi, Motohiko Kato, Naohisa Yahagi, Taisuke Kondo, Eri Arai, Yuko Kitagawa, Kenro Hirata, Yasuo Hamamoto, Takanori Kanai, Tomohisa Sujino (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13476903.txt.
Description
Kai Tsugaru and colleagues studied d-serine, a mirror-form amino acid, as a hidden brake on the immune attack against stomach tumours. Amino acids are the building blocks of proteins, and the d-form is the flipped twin of the usual l-form.
In mouse tumours, d-serine weakened killer T cells and boosted suppressive macrophages, the immune cells that calm attacks down. Blood, urine, and stool levels of d-serine ran higher in stomach cancer patients than in 87 healthy controls. Higher blood levels tracked later disease stages across the patient groups studied. Patients with high levels also answered poorly to a standard immune therapy drug, marking d-serine as a warning sign.
Catalog record
| CREATOR | Kai Tsugaru, Shohei Suzuki, Kentaro Miyamoto, Kazuhiro Murakami, Akihiko Chida, Chihiro Kato, Naoto Fukasawa, Arina Shigehara, Mai Hasegawa, Yusuke Yoshimatsu, Jumpei Sasabe, Masashi Mita, Nick Barker, Yosuke Harada, Yasutaka Sukawa, Toshiaki Teratani, Nobuhiro Nakamoto, Hirofumi Kawakubo, Kaoru Takabayashi, Motohiko Kato, Naohisa Yahagi, Taisuke Kondo, Eri Arai, Yuko Kitagawa, Kenro Hirata, Yasuo Hamamoto, Takanori Kanai, Tomohisa Sujino |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 103 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |