High and intermittent hydrostatic pressure promotes maturation of engineered cardiac tissues derived from human pluripotent stem cells
Wusiman Maihemuti, Kozue Murata, Takahiro Jimba, Jun Iida, Keisuke Hakamada, Akane Sakaguchi, Mosha Abulaiti, Yuichi Saito, Laura Yuriko González-Teshima, Satoshi Takatori, Takahiro Kenmotsu, Kenichi Yoshikawa, Kenji Minatoya, Seitaro Nomura, Wataru Kimura, Hidetoshi Masumoto · 2026
Read High and intermittent hydrostatic pressure promotes maturation of engineered cardiac tissues derived from human pluripotent stem cells by Wusiman Maihemuti, Kozue Murata, Takahiro Jimba, Jun Iida, Keisuke Hakamada, Akane Sakaguchi, Mosha Abulaiti, Yuichi Saito, Laura Yuriko González-Teshima, Satoshi Takatori, Takahiro Kenmotsu, Kenichi Yoshikawa, Kenji Minatoya, Seitaro Nomura, Wataru Kimura, Hidetoshi Masumoto (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13476875.txt.
Description
Wusiman Maihemuti and co-authors train lab-grown heart tissue in 2026 with pulses of water pressure to speed its maturation. Stem-cell heart tissue stays immature, which limits repair use. Tissue built from heart and vessel cells plus matrix got one hour of pressure daily for three days after two weeks of growth. Single-cell reading and function tests judged maturity.
Pressure-trained tissue showed aligned muscle cells, richer energy parts, and stronger contraction and calcium flow. Vessel cells proved required, since tissue without them failed to mature. Pressure plus flow also grew vessel networks inside the tissue. Grafts of trained tissue lifted heart pump scores in rats after heart attack.
Catalog record
| CREATOR | Wusiman Maihemuti, Kozue Murata, Takahiro Jimba, Jun Iida, Keisuke Hakamada, Akane Sakaguchi, Mosha Abulaiti, Yuichi Saito, Laura Yuriko González-Teshima, Satoshi Takatori, Takahiro Kenmotsu, Kenichi Yoshikawa, Kenji Minatoya, Seitaro Nomura, Wataru Kimura, Hidetoshi Masumoto |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80690 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |