Synergistic cell-cycle repression by HDAC/EZH2 co-targeting in H3K27-altered diffuse midline glioma
Zili Zhen, Qiang Gao, Yong Ai, Zhihong Qian, Yukui Shang, Yafang Deng, Shuai Chen, Xin Ni, Wei Zhang · 2026
Read Synergistic cell-cycle repression by HDAC/EZH2 co-targeting in H3K27-altered diffuse midline glioma by Zili Zhen, Qiang Gao, Yong Ai, Zhihong Qian, Yukui Shang, Yafang Deng, Shuai Chen, Xin Ni, Wei Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13476686.txt.
Description
Zili Zhen and co-authors pair two epigenetic drugs in 2026 against a deadly child brain tumor called diffuse midline glioma. The tumor carries a histone fault that scrambles gene control genome-wide. Stem-like tumor cells from brainstem and spinal tumors of patients fed drug tests. Two blockers, one for each of two gene-silencing systems, were tried alone and together.
The pair worked far better together than alone across the cell panel. Growth, self-renewal, and division programs fell while death and maturation signals rose. Stem-cell share dropped by more than ninety percent under the pair. In mouse implants, the pair shrank tumors, cut spinal spread, and lengthened survival.
Catalog record
| CREATOR | Zili Zhen, Qiang Gao, Yong Ai, Zhihong Qian, Yukui Shang, Yafang Deng, Shuai Chen, Xin Ni, Wei Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |