Long non-coding RNAs in the CFTR locus: New transcriptional regulators of CFTR gene expression
Jessica Varilh, Karine Deletang, Arnaud Bourdin, Prisca Boisguerin, Magali Taulan-Cadars · 2026
Read Long non-coding RNAs in the CFTR locus: New transcriptional regulators of CFTR gene expression by Jessica Varilh, Karine Deletang, Arnaud Bourdin, Prisca Boisguerin, Magali Taulan-Cadars (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13476513.txt.
Description
Jessica Varilh and co-authors find fresh long RNA regulators in 2026 around the gene faulty in cystic fibrosis. The gene, CFTR, is weakly active in adult tissue and ringed by control elements. New long RNAs from its neighborhood varied across human tissues. One, named CF006, lifted gene activity and raised both message and protein levels in tests.
CF006 ran low in airway cells rebuilt from patient donors. It may act at the gene start site and through local control proteins together. A small RNA known to run high in the disease also held CF006 down. Raising CF006 could become a care route beside current corrector drugs.
Catalog record
| CREATOR | Jessica Varilh, Karine Deletang, Arnaud Bourdin, Prisca Boisguerin, Magali Taulan-Cadars |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |