Engrailed-1 potentiates mitochondrial transplant neuroprotection in spinal cord ischemia-reperfusion injury
Wei Wang, Rui Tang, Shilun Gao, Xiaotian Han, Teng Shi, Tianxiang Gu, Enyi Shi · 2026
Read Engrailed-1 potentiates mitochondrial transplant neuroprotection in spinal cord ischemia-reperfusion injury by Wei Wang, Rui Tang, Shilun Gao, Xiaotian Han, Teng Shi, Tianxiang Gu, Enyi Shi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13476436.txt.
Description
Wei Wang and co-authors boost mitochondria transplant therapy for spinal cord injury in this 2026 study. When blood returns to a starved cord, power plant failure kills neurons. Donated mitochondria help, but weakly. A gene switch named Engrailed-1, low after injury, emerged as a lever.
Restoring the switch calmed harmful oxygen species and kept cell power steady, partly through a growth factor it turns on. Mitochondria from switch-boosted cells carried better energy profiles and entered neurons faster. In rats, transplant of the boosted organelles saved tissue and improved movement. Silencing the growth factor erased the gains, pinning the effect down.
Catalog record
| CREATOR | Wei Wang, Rui Tang, Shilun Gao, Xiaotian Han, Teng Shi, Tianxiang Gu, Enyi Shi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |