Revisiting the activate depress free and repeat (ADFR) paradigm: Clinical use of cyclic romosozumab
Kristyn Hare, Shawna Wheeler, Christina Morganti, Diane Krueger, Donald Kimmel, Neil Binkley · 2026
Read Revisiting the activate depress free and repeat (ADFR) paradigm: Clinical use of cyclic romosozumab by Kristyn Hare, Shawna Wheeler, Christina Morganti, Diane Krueger, Donald Kimmel, Neil Binkley (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13476312.txt.
Description
Kristyn Hare and co-authors revisited a cyclic plan for osteoporosis care in a 2026 paper. Bone loss in this disease is treated with drugs that build bone and drugs that slow its loss, but care still does not bring bone density back to normal. The cyclic idea runs build, press down, rest, then repeat, in set rounds.
Their cycle gave six monthly doses of a bone-building drug, then one dose of a loss-slowing drug. The gains in spine and hip density matched what twelve straight building doses had given in past reports. A second cycle added more density, though the boost was blunted. The plan may stretch a costly drug further.
Catalog record
| CREATOR | Kristyn Hare, Shawna Wheeler, Christina Morganti, Diane Krueger, Donald Kimmel, Neil Binkley |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |