The Sialomucin CD43 Drives Tuberculosis Immunopathology Across Different Host Genetic Backgrounds
Estefanía Alemán-Navarro, Dulce A. Mata-Espinosa, Manuel O. López-Torres, Jorge A. Barrios-Payán, Ángel F. Flores-Alcantar, Erika I. Melchy-Pérez, Rogelio Hernández-Pando, Yvonne Rosenstein · 2026
Read The Sialomucin CD43 Drives Tuberculosis Immunopathology Across Different Host Genetic Backgrounds by Estefanía Alemán-Navarro, Dulce A. Mata-Espinosa, Manuel O. López-Torres, Jorge A. Barrios-Payán, Ángel F. Flores-Alcantar, Erika I. Melchy-Pérez, Rogelio Hernández-Pando, Yvonne Rosenstein (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13476292.txt.
Description
Estefanía Alemán-Navarro and co-authors test a surface protein called CD43 in 2026 as a driver of lung harm in tuberculosis. Two mouse lines with opposite immune leanings were infected and compared with and without the protein. Removing CD43 cut lung inflammation and raised survival in both lines. The paths to that gain differed by line, though.
In one line, removal lifted early defense signals and later calmed inflammation, which improved germ control. In the other, removal slowed defense signals and cut cell buildup without better germ control. Host immune leaning shapes what a single protein does. Tuberculosis care may need tailoring by immune type.
Catalog record
| CREATOR | Estefanía Alemán-Navarro, Dulce A. Mata-Espinosa, Manuel O. López-Torres, Jorge A. Barrios-Payán, Ángel F. Flores-Alcantar, Erika I. Melchy-Pérez, Rogelio Hernández-Pando, Yvonne Rosenstein |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54429 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |