An engineered anti-Oropouche virus human-murine chimeric immunoglobulin M is a viable substitute for positive human serum controls in diagnostic serology assays
Kerri L Miazgowicz, Christin H Goodman, Amanda E Calvert, Daniel Limonta, Daniel Limonta, David Safronetz, Stephanie Seifert, Daniel Limonta, Stephanie Seifert, Daniel Limonta · 2026
Read An engineered anti-Oropouche virus human-murine chimeric immunoglobulin M is a viable substitute for positive human serum controls in diagnostic serology assays by Kerri L Miazgowicz, Christin H Goodman, Amanda E Calvert, Daniel Limonta, Daniel Limonta, David Safronetz, Stephanie Seifert, Daniel Limonta, Stephanie Seifert, Daniel Limonta (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13475966.txt.
Description
Kerri L Miazgowicz and co-authors engineer a lab-made antibody in 2026 to stand in for scarce human serum in Oropouche virus tests. The virus has spread wider in recent years and can harm unborn babies. Diagnosis leans on two lab tests that need positive control material, usually from past patients. The team fused a mouse antibody targeting a virus coat protein onto a human antibody frame.
The engineered control matched a strong mouse reference fluid at blocking live virus. In the capture test it beat real patient sera as a control. Made in bulk, it offers steady strength from batch to batch. Labs gain a renewable control for outbreak response.
Catalog record
| CREATOR | Kerri L Miazgowicz, Christin H Goodman, Amanda E Calvert, Daniel Limonta, Daniel Limonta, David Safronetz, Stephanie Seifert, Daniel Limonta, Stephanie Seifert, Daniel Limonta |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |