Anti-Human Epidermal Growth Factor Receptor 2 therapies in metastatic colorectal cancer: a systematic review and meta-analysis
Simone Rota, Paola Di Nardo, Emma Zottarelli, Fabiola Giudici, Riccardo Vida, Miriam Zilli, Marco de Scordilli, Luisa Foltran, Arianna Fumagalli, Michela Guardascione, Elena Ongaro, Fabio Puglisi · 2026
Read Anti-Human Epidermal Growth Factor Receptor 2 therapies in metastatic colorectal cancer: a systematic review and meta-analysis by Simone Rota, Paola Di Nardo, Emma Zottarelli, Fabiola Giudici, Riccardo Vida, Miriam Zilli, Marco de Scordilli, Luisa Foltran, Arianna Fumagalli, Michela Guardascione, Elena Ongaro, Fabio Puglisi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13475379.txt.
Description
Simone Rota and co-authors pool trial evidence on HER2-targeted treatment for metastatic colorectal cancer with HER2 amplification, a subgroup with poorer prognosis and resistance to standard EGFR therapy. Their 2026 systematic review and meta-analysis includes phase two and three trials of anti-HER2 regimens without added chemotherapy.
Ten trials covering 467 patients tested five combinations built around trastuzumab. Across them, about a third of patients responded and just over two thirds achieved disease control, with weighted median survival of 13.4 months and time without progression of five and a half months. Two regimens stood out: trastuzumab deruxtecan and trastuzumab with tucatinib showed higher response and control rates than the older dual blockade of trastuzumab plus pertuzumab. The authors conclude anti-HER2 therapy works in pretreated patients, while noting further studies are needed to confirm the ranking.
Catalog record
| CREATOR | Simone Rota, Paola Di Nardo, Emma Zottarelli, Fabiola Giudici, Riccardo Vida, Miriam Zilli, Marco de Scordilli, Luisa Foltran, Arianna Fumagalli, Michela Guardascione, Elena Ongaro, Fabio Puglisi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |