Application of next-generation sequencing in nonimmune hydrops fetalis and its impact on pregnancy decisions
Yu Qin, Wei Li, Sha Zhu, Shunran Zhang, Ruijie Fang, Qingling Kang, Lei Fan, Jing Liu, Shufang Li, Jianli Wu, Yuanyuan Wu, Xinwei Shi, Ling Feng, Suhua Chen, Juan Xiao · 2026
Read Application of next-generation sequencing in nonimmune hydrops fetalis and its impact on pregnancy decisions by Yu Qin, Wei Li, Sha Zhu, Shunran Zhang, Ruijie Fang, Qingling Kang, Lei Fan, Jing Liu, Shufang Li, Jianli Wu, Yuanyuan Wu, Xinwei Shi, Ling Feng, Suhua Chen, Juan Xiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13474967.txt.
Description
Yu Qin and co-authors apply gene sequencing in 2026 to fetuses with fluid buildup not caused by blood mismatch. This state, called nonimmune hydrops, has many possible causes and a high loss rate. Records covered 121 pregnancies at one referral center over three years. All got copy-number sequencing, and ninety-five also got full exome reading.
Just over half of cases gained a firm genetic answer. Copy-number reading alone solved about two fifths, covering whole chromosome errors and smaller structural faults. Exome reading added answers in about one seventh of those tested, led by growth-pathway and bone disorders. Early diagnosis age raised the solve rate, and results shaped pregnancy choices.
Catalog record
| CREATOR | Yu Qin, Wei Li, Sha Zhu, Shunran Zhang, Ruijie Fang, Qingling Kang, Lei Fan, Jing Liu, Shufang Li, Jianli Wu, Yuanyuan Wu, Xinwei Shi, Ling Feng, Suhua Chen, Juan Xiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54067 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |